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June 2013 Briefing - Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for June 2013. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Glucosamine Negatively Affects Lumbar Discs

FRIDAY, June 28 (HealthDay News) -- Glucosamine supplementation, which is often used for low back pain, has a detrimental effect on lumbar disc matrix homeostasis in an animal model of disc degeneration, according to a study published in the May 20 issue of Spine.

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Low-Income Patients Skip Rheumatoid Arthritis Meds

FRIDAY, June 28 (HealthDay News) -- Electronic monitoring shows that ethnically diverse and economically disadvantaged patients with rheumatoid arthritis (RA) have low adherence to oral disease-modifying antirheumatic drugs (DMARDs) and poorer outcomes, according to a study published in the June issue of Arthritis & Rheumatism.

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Lithium Cuts Suicide Risk for Patients With Mood Disorders

FRIDAY, June 28 (HealthDay News) -- For people with mood disorders, lithium reduces the risk of suicide, according to a review and meta-analysis published online June 27 in BMJ.

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Marine n-3 PUFA Inversely Linked to Breast Cancer Risk

FRIDAY, June 28 (HealthDay News) -- Marine n-3 polyunsaturated fatty acid (n-3-PUFA) intake is inversely associated with the risk of breast cancer, according to a review published online June 27 in BMJ.

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Avoidable Health Care Costs Exceed $200 Billion in 2012

FRIDAY, June 28 (HealthDay News) -- In 2012, avoidable health care costs in the United States exceeded $200 billion, according to a report published by the IMS Institute for Healthcare Informatics.

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Bipartisan Recommendations Can Strengthen Health System

THURSDAY, June 27 (HealthDay News) -- Leaders of the Bipartisan Policy Center Health Care Cost Containment Initiative have developed a series of recommendations to strengthen the U.S. health care system, according to a sounding board piece published online June 26 in the New England Journal of Medicine.

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Simvastatin Blunts Benefits of Exercise in Overweight, Obese

THURSDAY, June 27 (HealthDay News) -- Cholesterol-lowering therapy with simvastatin reduces the physiological responses to aerobic exercise training in overweight or obese adults who are at increased risk for metabolic syndrome, according to research published in the Journal of the American College of Cardiology.

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FDA Approves Rixubis for Prophylactic Tx in Hemophilia B

THURSDAY, June 27 (HealthDay News) -- Rixubis (coagulation factor IX recombinant) has been approved by the U.S. Food and Drug Administration to prevent routine bleeding episodes in people aged 16 and older with hemophilia B, the agency said in a news release.

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Study Examines Opiate Use in Orthopedic Trauma Patients

THURSDAY, June 27 (HealthDay News) -- Orthopedic trauma patients with isolated musculoskeletal injuries are significantly more likely than the general population to have used prescription opiates prior to injury, and pre-injury use predicts prolonged postoperative use, according to a study published in the June 19 issue of The Journal of Bone & Joint Surgery.

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Escitalopram Plus Behavior Tx Benefits Elderly With Anxiety

THURSDAY, June 27 (HealthDay News) -- For older adults with generalized anxiety disorder, escitalopram combined with cognitive behavioral therapy (CBT) is associated with a reduction in worry and can prevent relapse, according to a study published online May 17 in the The American Journal of Psychiatry.

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Antibiotic Exposure in Infancy Linked to Subsequent Eczema

THURSDAY, June 27 (HealthDay News) -- Exposure to antibiotics in the first year of life is associated with an increased likelihood of eczema, with increasing risk seen for each additional course of antibiotics, according to research published online June 20 in the British Journal of Dermatology.

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Hundreds of Docs Have Dubious Prescribing Patterns in Part D

THURSDAY, June 27 (HealthDay News) -- Many hundreds of general-care physicians who order drugs paid for by Medicare Part D have questionable prescribing patterns, according to a report published by the U.S. Department of Health and Human Services (HHS).

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Adults With Chronic Conditions Earn C+ for Meds Adherence

WEDNESDAY, June 26 (HealthDay News) -- On average, adults with chronic conditions earn a C+ for medication adherence, according to a report published June 25 by the National Community Pharmacists Association (NCPA).

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8.5 Million Enrollees to Receive Health Insurance Rebates

WEDNESDAY, June 26 (HealthDay News) -- About 8.5 million enrollees will receive a rebate of about $100 per family as part of the Affordable Care Act "80/20" rule, according to a report published by the U.S. Department of Health and Human Services.

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HHS Launches Insurance Marketplace Website, Call Center

WEDNESDAY, June 26 (HealthDay News) -- The U.S. Department of Health and Human Services (HHS) has launched the Health Insurance Marketplace education effort, with a consumer-focused website and a consumer call center, to help Americans prepare for enrollment in the new Health Insurance Marketplace.

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Ibrutinib Promotes Remission in Chronic Lymphocytic Leukemia

WEDNESDAY, June 26 (HealthDay News) -- A new drug that targets interactions with the tumor microenvironment promotes remission in patients with relapsed chronic lymphocytic leukemia, according to a study published online June 19 in the New England Journal of Medicine.

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Gene Mutation Influences Aspirin's Colon Cancer Benefit

TUESDAY, June 25 (HealthDay News) -- Regular aspirin use is associated with a lower risk of developing colorectal cancer, but only cancers without mutations in the BRAF oncogene, according to a study published in the June 26 issue of the Journal of the American Medical Association.

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Publicly Reported Mortality Predicts Hospital Performance

TUESDAY, June 25 (HealthDay News) -- Hospital performance on publicly reported medical conditions is indicative of overall hospital mortality rates, according to a study published online June 24 in JAMA Internal Medicine.

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Drop in HPV Prevalence in 14- to 19-Year Olds in Vaccine Era

TUESDAY, June 25 (HealthDay News) -- The prevalence of vaccine-type human papillomavirus (HPV) among 14- to 19-year old females decreased within four years of introduction of vaccination into routine immunization schedules in late 2006, according to research published online June 19 in the Journal of Infectious Diseases.

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AH: Most Acute Care Costs Not Avoidable for High-Cost Patients

MONDAY, June 24 (HealthDay News) -- For high-cost Medicare beneficiaries, only a small percentage of costs are related to preventable emergency department visits and hospitalizations, according to a study published online June 24 in the Journal of the American Medical Association to coincide with presentation at the Annual Research Meeting of AcademyHealth, held from June 23 to 25 in Baltimore.

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FDA Approves Vibativ for Certain Bacterial Pneumonias

MONDAY, June 24 (HealthDay News) -- The antibiotic Vibativ (telavancin) has been approved by the U.S. Food and Drug Administration to treat hospital-acquired and ventilator-associated bacterial pneumonia caused by Staphylococcus aureus bacteria when other treatments aren't suitable.

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No Long-Term Cognitive Consequences Noted for HRT

MONDAY, June 24 (HealthDay News) -- For postmenopausal women aged 50 to 55 years, conjugated equine estrogen (CEE)-based hormone therapy has no long-term impact on cognition, according to research published online June 24 in JAMA Internal Medicine.

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Survival of England's National Health Service Questioned

MONDAY, June 24 (HealthDay News) -- Recent criticism of England's National Health Service (NHS) has called its survival into question, according to a perspective piece published online June 19 in the New England Journal of Medicine.

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Local Vancomycin Reduces Infections in Cervical Fusion

MONDAY, June 24 (HealthDay News) -- The local application of prophylactic vancomycin significantly reduces the risk of surgical site infections in patients undergoing multilevel posterior cervical-instrumented fusions for cervical spondylotic myelopathy (CSM), according to a study published in the June 15 issue of Spine.

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AAP Updates Guidelines for Bacterial Sinusitis in Children

MONDAY, June 24 (HealthDay News) -- The American Academy of Pediatrics (AAP) has updated its recommendations for the diagnosis and management of acute bacterial sinusitis in children; the updated clinical practice guideline has been published online June 24 in Pediatrics.

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Racial Disparity Seen in ADHD Diagnosis, Tx for Children

MONDAY, June 24 (HealthDay News) -- Racial/ethnic minority children are less likely than white children to receive a diagnosis of attention-deficit/hyperactivity disorder (ADHD), and are less likely to take prescription medications for ADHD, according to a study published online June 24 in Pediatrics.

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Guide Issued for Tying Primary Care to Regional Organizations

MONDAY, June 24 (HealthDay News) -- The Agency for Healthcare Research and Quality has developed a new guide to help primary care practices to assess readiness for connecting electronic health records (EHRs) to regional health information organizations (RHIOs).

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CDC: Flu Vaccine Option Available for People With Egg Allergy

FRIDAY, June 21 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) has unanimously voted to recommend FluBlok for people 18 through 49 years of age requiring the 2013-2014 influenza vaccine but who have an egg allergy or sensitivity.

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FDA Approves Plan B for All Females of Childbearing Age

FRIDAY, June 21 (HealthDay News) -- The Plan B "emergency" contraceptive (levonorgestrel) has been approved by the U.S. Food and Drug Administration for any female of childbearing potential.

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AHRQ Offers Strategies to Prevent Adverse Drug Events

FRIDAY, June 21 (HealthDay News) -- Strategies to prevent adverse drug events (ADEs) have been recommended and published in a report by the Agency for Healthcare Research and Quality (AHRQ).

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Obesity Is a Disease, Says American Medical Association

THURSDAY, June 20 (HealthDay News) -- The American Medical Association has adopted policy that recognizes obesity as a disease, a step that the association hopes will help focus more attention on treatment and prevention efforts, and that some suggest may lead to greater acceptance by insurance providers to cover treatment.

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Bolus Iron Dosing Ups Infection Risk in Hemodialysis Patients

THURSDAY, June 20 (HealthDay News) -- For hemodialysis patients, bolus dosing of iron is associated with an increased risk of infection-related hospitalization, compared with receiving maintenance iron dosing, especially for patients with a catheter or with recent infection, according to a study published online June 20 in the Journal of the American Society of Nephrology.

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Practices Are Not Prepared for Implementation of ICD-10

THURSDAY, June 20 (HealthDay News) -- Physician practices have made little progress in preparing for implementation of the 10th revision of the International Classification of Diseases (ICD-10), according to a report published by the Medical Group Management Association (MGMA).

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CDC Releases Modified Contraception Recommendations

THURSDAY, June 20 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has issued modified recommendations for health care providers regarding the safe and effective use of contraceptive methods; the report, "U.S. Selected Practice Recommendations for Contraceptive Use 2013," has been published in the June 14 early-release issue of the CDC's Morbidity & Mortality Weekly Report.

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Ibrutinib Active in Refractory or Relapsed Mantle-Cell Lymphoma

WEDNESDAY, June 19 (HealthDay News) -- The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib is active in relapsed or refractory mantle-cell lymphoma, with a response rate of 68 percent, according to a study published online June 19 in the New England Journal of Medicine.

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Clopidogrel Does Not Reduce Mortality in Shunted Infants

WEDNESDAY, June 19 (HealthDay News) -- In infants less than 3 months old with congenital heart disease and a systemic-to-pulmonary-artery shunt, clopidogrel does not reduce mortality compared with placebo, according to a study published in the June 20 issue of the New England Journal of Medicine.

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Potential of Mobile Remote-Presence Devices Discussed

WEDNESDAY, June 19 (HealthDay News) -- Mobile remote-presence devices have the potential to increase access to and improve delivery of health care in the developed and developing world, according to an innovations report published online June 17 in CMAJ, the Journal of the Canadian Medical Association.

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FDA Investigates Deaths of Patients on Antipsychotic Drug

WEDNESDAY, June 19 (HealthDay News) -- Following the deaths of two patients three to four days after receiving a dose of Zyprexa Relprevv (olanzapine pamoate) via intramuscular injection, the U.S. Food and Drug Administration is conducting an investigation into the possible cause.

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Penicillin Skin Testing Can ID Tolerance to β-Lactam Agents

WEDNESDAY, June 19 (HealthDay News) -- Penicillin skin testing (PST) can be used to identify whether patients will tolerate β-lactam, with a negative predictive value of 100 percent, according to a study published in the June issue of the Journal of Hospital Medicine.

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New Rule Proposes Insurance Program Integrity Guidelines

WEDNESDAY, June 19 (HealthDay News) -- A new proposed rule, which provides program integrity guidelines for Affordable Insurance Exchanges, or Health Insurance Marketplaces (Marketplaces), has been released by the U.S. Department of Health and Human Services (HHS).

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EHR Implementation First Step Toward Quality Improvement

WEDNESDAY, June 19 (HealthDay News) -- Implementation of electronic health records (EHRs) is a first step toward quality improvement and should be accompanied by use of new payment models to allow physicians to see a return on their investments, according to Farzad Mostashari, M.D., of the Office of the National Coordinator for Health Information Technology, who was recently interviewed by the American Academy of Family Physicians.

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State-Based Health Care Price Websites Lacking

TUESDAY, June 18 (HealthDay News) -- State-based, patient-oriented websites reporting health care prices need to be improved, according to a research letter published in the June 19 issue of the Journal of the American Medical Association.

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MRI Screening Identifies Undiagnosed Spinal Infections

TUESDAY, June 18 (HealthDay News) -- About a fifth of patients who have received a spinal injection of fungus-contaminated methylprednisolone but have not sought medical care are likely to be infected, according to a study published in the June 19 issue of the Journal of the American Medical Association.

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Unauthorized Immigrants Make Up 1.4% U.S. Medical Spending

TUESDAY, June 18 (HealthDay News) -- Unauthorized immigrants have substantially lower health care expenditures than legal residents, naturalized citizens, and U.S. natives, according to a study published online June 12 in Health Affairs.

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About 15 Percent of People Currently Uninsured in U.S.

TUESDAY, June 18 (HealthDay News) -- In 2012, nearly 15 percent of U.S. people of all ages were currently uninsured, according to a data brief published online June 18 by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Some Antibiotics Up Risk of Statin Toxicity in Older Adults

MONDAY, June 17 (HealthDay News) -- In older adults, concomitant administration of clarithromycin, or erythromycin, with a statin that is metabolized by cytochrome P450 isoenzyme 3A4 (CYP3A4) increases the risk for statin toxicity, according to research published in the June 18 issue of the Annals of Internal Medicine.

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FDA Discusses Cybersecurity for Medical Devices, Hospitals

MONDAY, June 17 (HealthDay News) -- Medical device manufacturers and health care facilities should ensure appropriate safeguards are in place to reduce the potential harms that may result from cyberattacks, according to a safety communication issued by the U.S. Food and Drug Administration.

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Initiating Statins Linked to Increased Risk of T2DM

MONDAY, June 17 (HealthDay News) -- Initiating statin therapy is associated with an increased risk of type 2 diabetes, which is not explained by differential survival, according to a study published in the May issue of Diabetes Care.

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Duloxetine Moderately Cost-Effective for Treating Back Pain

FRIDAY, June 14 (HealthDay News) -- Duloxetine is a moderately cost-effective treatment for chronic low back pain (CLBP) compared with other post-first-line oral medications, according to research published in the May 15 issue of Spine.

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New Treatments Outperforming Placebo Becoming Less Common

FRIDAY, June 14 (HealthDay News) -- The efficacy of new medical treatments compared with placebo has sharply declined over the last few decades, suggesting that comparative effectiveness studies are needed, according to a study published in the June issue of Health Affairs.

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Radiation + Tamoxifen Lowers Risk of Locoregional Recurrence

FRIDAY, June 14 (HealthDay News) -- Over the long term, treatment with radiation plus tamoxifen for early-stage breast cancer leads to a small benefit in locoregional recurrence, but not in an advantage for overall survival, distant disease-free survival, or breast preservation, according to a study published online May 20 in the Journal of Clinical Oncology.

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School-Based Flu Vaccinations Cost-Effective

THURSDAY, June 13 (HealthDay News) -- School-located vaccination against influenza (SLV-I) is a cost-effective means to improve childhood influenza vaccination rates, according to a study published in the April 19 issue of Vaccine.

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FDA Approves Xgeva for Rare, Non-Malignant Tumor

THURSDAY, June 13 (HealthDay News) -- Xgeva (denosumab) has been approved by the U.S. Food and Drug Administration to treat giant cell tumor of the bone (GCTB), a rare tumor that's most often non-cancerous.

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FDA: One Lot of Warfarin Being Recalled

THURSDAY, June 13 (HealthDay News) -- Zydus Pharmaceuticals USA Inc., is voluntarily recalling one lot of Warfarin tablets after receiving a consumer complaint of oversized tablets, according to a June 12 safety alert issued by the U.S. Food and Drug Administration.

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Metformin Doesn't Reduce Gestational Diabetes With PCOS

THURSDAY, June 13 (HealthDay News) -- Metformin does not reduce the occurrence of gestational diabetes (GD) among pregnant women with polycystic ovarian syndrome (PCOS) treated with metformin throughout pregnancy, according to a small study published in the June issue of Diabetes Care.

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Tenofovir Prophylaxis Cuts HIV Transmission in Drug Users

THURSDAY, June 13 (HealthDay News) -- For injecting drug users, daily oral use of an antiretroviral, tenofovir disoproxil fumarate (tenofovir), can reduce the risk of HIV transmission, according to a study published online June 13 in The Lancet.

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Survey Examines Physician Satisfaction With EHRs

THURSDAY, June 13 (HealthDay News) -- About three-quarters of physicians report that their practice either has a fully implemented electronic health record (EHR), uses a hospital or corporate EHR, or is in the process of implementing an EHR, according to a technology survey published by Physicians Practice.

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Use of EHRs Can Enhance Doc-Patient Communication

WEDNESDAY, June 12 (HealthDay News) -- Electronic health records (EHRs) can be used during clinical encounters to enhance the physician-patient relationship, encouraging communication during the clinical encounter, according to a viewpoint published in the June 12 issue of the Journal of the American Medical Association.

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Education, Audit, Feedback Improve Antibiotic Rx

TUESDAY, June 11 (HealthDay News) -- Clinician education coupled with audit and feedback can improve adherence of antibiotic prescribing guidelines for common bacterial acute respiratory tract infections (ARTIs), according to a study published in the June 12 issue of the Journal of the American Medical Association.

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Doctors Do Not Spend Enough Time Planning Their Finances

TUESDAY, June 11 (HealthDay News) -- Physicians do not spend enough time reviewing their finances, and half are behind in their retirement planning, according to a report published by the American Medical Association (AMA) Insurance Agency.

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Most Doctors Feel They Are Under-Using Mobile Apps

TUESDAY, June 11 (HealthDay News) -- Most physicians feel they are not maximizing use of mobile applications, and would utilize additional electronic health record (EHR) functionalities if they were available, according to poll conducted by Black Book Market Research.

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Medicare Beneficiaries Use More Brand-Name Drugs Than VA

TUESDAY, June 11 (HealthDay News) -- Compared to seniors with diabetes treated through Veterans Affairs (VA), Medicare beneficiaries with diabetes use two to three times more brand-name drugs, driving up costs substantially, according to research published online June 11 in the Annals of Internal Medicine.

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Lumbar Epidural Steroid Injections Up Risk of Spinal Fx

MONDAY, June 10 (HealthDay News) -- In patients with radiculopathy or neurogenic claudication due to compression of spinal nerves, lumbar epidural steroid injections (LESIs) increase the risk of vertebral fractures, according to a study published in the June 5 issue of The Journal of Bone & Joint Surgery.

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Fidaxomicin Ups Outcome of C. difficile-Tied Diarrhea in Cancer

MONDAY, June 10 (HealthDay News) -- For patients with cancer with Clostridium difficile-associated diarrhea (CDAD), fidaxomicin treatment is associated with improved outcomes compared with vancomycin treatment, according to research published online May 28 in the Journal of Clinical Oncology.

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Depression, Antidepressant Use Linked to Future CVD Risk

MONDAY, June 10 (HealthDay News) -- For patients with type 2 diabetes, higher self-reported depression symptoms and antidepressant medicine (ADM) use in the previous year are independently associated with developing certain cardiovascular disease (CVD) risk factor-positive status over the next four years, according to a study published in the May issue of Diabetes Care.

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Higher Vitamin D Linked to Reduced Diabetes Risk

FRIDAY, June 7 (HealthDay News) -- Higher blood levels of vitamin D are associated with a lower risk of type 2 diabetes, according to a meta-analysis published in the May issue of Diabetes Care.

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Methylphenidate, Nurses Calls Don't Improve Cancer Fatigue

FRIDAY, June 7 (HealthDay News) -- For patients with advanced cancer, methylphenidate (MP) or a nursing telephone intervention (NTI), alone or combined, offer no benefit over placebo for improving cancer-related fatigue (CRF), according to a study published online May 20 in the Journal of Clinical Oncology.

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Large Randomized Trial Will Compare Diabetes Medications

FRIDAY, June 7 (HealthDay News) -- The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) is a pragmatic clinical trial that will compare the long-term effects of diabetes medications (when combined with metformin) on glucose-lowering efficacy and patient-centered outcomes, according to a report published online May 20 in Diabetes Care.

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FDA Panel Votes to Loosen Restrictions on Avandia

FRIDAY, June 7 (HealthDay News) -- A U.S. Food and Drug Administration advisory panel met Wednesday and Thursday to discuss the fate of the diabetes drug Avandia (rosiglitazone), concluding in a vote in favor of easing restrictions on access to the drug. The exact nature of these restriction changes are yet to be determined.

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Lixisenatide Non-Inferior to Exenatide for Diabetes

THURSDAY, June 6 (HealthDay News) -- In adults with type 2 diabetes not adequately controlled with metformin, lixisenatide once daily offers diabetes control similar to that of exenatide twice daily, with some added benefits, according to a study published online May 22 in Diabetes Care.

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Fish Oil Supplementation May Lower Risk of Diabetes

THURSDAY, June 6 (HealthDay News) -- Fish oil supplementation moderately increases circulating adiponectin, according to a review published in the June 1 issue of the Journal of Clinical Endocrinology & Metabolism.

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Statins May Lower Esophageal Cancer Risk

THURSDAY, June 6 (HealthDay News) -- Statins may lower the risk of esophageal cancer, particularly in patients with Barrett's esophagus, according to a review published in the June issue of Clinical Gastroenterology and Hepatology.

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HHS: Marketplaces Open New Insurance Options for Consumers

THURSDAY, June 6 (HealthDay News) -- Health Insurance Marketplaces, due to be introduced in October 2013, will increase the coverage options for many consumers, according to a memo released by the U.S. Department of Human & Health Services.

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One-Third of Women Willing to Delay Rx for Suspected UTI

WEDNESDAY, June 5 (HealthDay News) -- When asked to by their doctor, more than a third of women with urinary tract infection symptoms are willing to delay antibiotic treatment, according to a study published online May 31 in BMC Family Practice.

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Aspirin Post Hip Replacement OK for Extended Prophylaxis

WEDNESDAY, June 5 (HealthDay News) -- Twenty-eight days of aspirin is non-inferior to, and as safe as, dalteparin, a low-molecular-weight heparin, for the prevention of venous thromboembolism (VTE) after total hip arthroplasty (THA), according to research published in the June 4 issue of the Annals of Internal Medicine.

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Twitter Analysis Can Inform Vaccination Campaigns

WEDNESDAY, June 5 (HealthDay News) -- Analysis of Twitter posts can help explain patient knowledge and inform directions for educational vaccination campaigns, according to a brief report published in the June issue of the American Journal of Infection Control.

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Few Physicians Meeting Meaningful Use in Early 2012

WEDNESDAY, June 5 (HealthDay News) -- In early 2012, few physicians met meaningful use criteria, and using electronic health records (EHRs) for patient panel management was difficult, according to research published in the June 5 issue of the Annals of Internal Medicine.

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CDC: Small Drop in Those With Difficulty Paying Medical Bills

TUESDAY, June 4 (HealthDay News) -- There has been a slight decrease in the percentage of individuals aged younger than 65 years who are in a family with difficulty paying their medical bills, according to a June data brief issued by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Biomarker Not Linked to Multiple Sclerosis Response

TUESDAY, June 4 (HealthDay News) -- Serum levels of interleukin 17F (IL-17F) during early treatment of multiple sclerosis with interferon beta are not associated with responsiveness to treatment, although levels greater than 200 pg/mL may predict lack of response, according to a study published online June 3 in JAMA Neurology.

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Flaxseed Ineffective for Hypercholesterolemia in Youth

TUESDAY, June 4 (HealthDay News) -- Dietary flaxseed supplementation in children with hypercholesterolemia is safe but associated with adverse changes in lipid profile with no clear benefit, according to a study published online June 3 in JAMA Pediatrics.

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Independent Payment Advisory Board's Future Questioned

MONDAY, June 3 (HealthDay News) -- Established as a part of the efforts of Affordable Care Act (ACA) to contain health care costs, the Independent Payment Advisory Board (IPAB) has been surrounded by controversy, and still has no members, according to a perspective piece published online May 29 in the New England Journal of Medicine.

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Increasing Drug Rx Linked to Exposure, Poisoning in Children

MONDAY, June 3 (HealthDay News) -- There is a strong correlation between increasing adult drug prescriptions and exposure and poisoning among children, particularly those aged 0 to 5 years, according to a study published online June 3 in Pediatrics.

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Religious Vaccine Exemptions Increasing in New York State

MONDAY, June 3 (HealthDay News) -- From 2000 to 2011 there was an increase in the rate of religious vaccination exemptions in New York State, which correlated with increased incidence of pertussis; and missed immunizations should be given at sick visits and not delayed until make-up well-baby visits, according to research published online June 3 in Pediatrics.

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Drug Resistant Cancers Have Alternative Drug Target

MONDAY, June 3 (HealthDay News) -- Cancers that develop resistance to anti-epidermal growth factor receptor (EGFR) treatments often have amplification of the MET gene, which can be targeted by drugs to overcome resistance, according to a study published online June 2 in Cancer Discovery.

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Bone Mineral Density Tx Can Be Effective for Young CF Patients

MONDAY, June 3 (HealthDay News) -- For children and young adults with cystic fibrosis, adequate calcium intake plus calcifediol can improve bone mineral density, while alendronate can increase bone mineral density for some non-responders, according to a study published online June 2 in The Lancet Respiratory Medicine.

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Health of Nation Reviewed With Focus on Emergency Care

MONDAY, June 3 (HealthDay News) -- Recent trends in the health of the nation are described, with particular focus on emergency care, in the 36th annual report published by the National Center for Health Statistics (NCHS) and the U.S. Centers for Disease Control and Prevention.

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