Community Health Network

Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.

Explore Community

Close
News

Ondansetron Not Linked to Adverse Fetal Outcomes

WEDNESDAY, Feb. 27 (HealthDay News) -- Administration of ondansetron for treatment of nausea during pregnancy is not associated with any increased risk of adverse fetal outcomes, according to a study published in the Feb. 28 issue of the New England Journal of Medicine.

To examine the risk of adverse fetal outcomes linked to ondansetron given during pregnancy, Björn Pasternak, M.D., Ph.D., from Statens Serum Institut in Denmark, and colleagues analyzed data from a historical cohort of 608,385 pregnancies including women who were exposed to ondansetron and those who were not exposed in a 1:4 ratio. The risk of spontaneous abortion, stillbirth, any major birth defect, preterm delivery, and birth of infants at low birth weight and small for gestational age were assessed in propensity-score-matched analyses.

The researchers found that exposure to ondansetron was not associated with a significantly increased risk of spontaneous abortion during gestational weeks 7 to 12 or during weeks 13 to 22. There was also no significantly increased risk of stillbirth, any major birth defect, preterm delivery, delivery of a low-birth-weight infant, or delivery of a small-for-gestational-age infant associated with receipt of ondansetron.

"Although these results cannot definitively rule out the possibility of adverse effects in association with ondansetron, the results do provide reassurance regarding the use of this agent for nausea and vomiting in pregnancy," the authors write.

Full Text (subscription or payment may be required)

Health News Copyright © 2013 HealthDay. All rights reserved.

Health Day

Proud sponsors

  • Indiana Fever
  • Indianapolis Indians
  • Indiana Pacers
  • Sarah Fisher Hartman Racing

Health and wellness shopping

  • Home Health Medical online store for medical supplies and equipment
  • Wellspring Pharmacy
  • FigLeaf Boutique
  • Jasmine gift shop