Community Health Network

Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.

Explore Community


Physician News

New Inflammatory Biomarker ID'd in Lumbar Disc Herniation

FRIDAY, Nov. 30 (HealthDay News) -- The leukocyte adhesion protein E-selectin is an inflammatory biomarker in the pathogenesis of lumbar disc herniation, according to a study published in the December issue of the Journal of Spinal Disorders & Techniques.

Kadir Tufan, M.D., of Baskent University in Ankara, Turkey, and colleagues conducted a study involving herniated disc specimens from 50 patients who had unilateral persistent radicular pain or unilateral radicular motor paresis to evaluate the prevalence of E-selectin with other inflammatory biomarkers, including CD20, CD45, and CD68. The authors assessed the relative risk of the straight-leg raising (SLR) test positivity or negativity in conjunction with CD20, CD45, CD68, and E-selectin staining.

The researchers found that immunostaining rates were higher with E-selectin and CD45 in cases with positive SLR. There was no significant association between positive SLR and CD20 or CD68.

"We suggest that E-selectin is as valuable as the other well-known inflammatory markers in the pathogenesis of lumbar disc herniation," the authors write. "In our opinion, other than well-known nonsteroidal anti-inflammatory drugs, antagonists targeting E-selectin can be potentially effective therapeutics for controlling inflammation in lumbar disc herniation."

Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

Health Day

Proud sponsor

  • Indiana Fever
  • Indianapolis Indians
  • Indiana Pacers
  • Ed Carpenter Racing
  • Indy Eleven
  • Indy Fuel

Health and wellness shopping

  • Wellspring Medical at Home for medical supplies and equipment
  • FigLeaf Boutique
  • Jasmine gift shop
  • Wellspring Pharmacy

More about shops