Community Health Network

Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.

Explore Community

Close
News

Physician News

Glucagon, GLP-1 Co-Infusion Can Reduce Appetite

WEDNESDAY, June 25, 2014 (HealthDay News) -- Co-infusion of glucagon and glucagon-like peptide 1 (GLP-1) correlates with a reduction in appetite, and GLP-1 protects against glucagon-induced hyperglycemia in healthy volunteers, according to a study published online June 17 in Diabetes.

Jaimini Cegla, M.B.B.S., from Imperial College London in the United Kingdom, and colleagues conducted a double-blind, cross-over study involving 13 human volunteers to examine the effect of administration of a combination of glucagon and GLP-1. Sub-anorectic doses of each peptide alone, in combination, or placebo were infused into volunteers for 120 minutes. After 90 minutes, an ad libitum meal was provided, and calorie intake was determined.

The researchers found that there was no significant reduction in food intake with either glucagon or GLP-1 given individually. Co-infusion led to a significant 13 percent reduction in food intake. The addition of GLP-1 also offered protection against glucagon-induced hyperglycemia; co-infusion correlated with a 53kcal/day increase in energy expenditure.

"These observations support the concept of GLP-1 and glucagon dual agonism as a possible treatment for obesity and diabetes," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2014 HealthDay. All rights reserved.

Health Day

Proud sponsors

  • Indiana Fever
  • Indianapolis Indians
  • Indiana Pacers
  • Sarah Fisher Hartman Racing
  • Indy Eleven
  • Indy Fuel

Health and wellness shopping

  • Home Health Medical online store for medical supplies and equipment
  • Wellspring Pharmacy
  • FigLeaf Boutique
  • Jasmine gift shop