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Interventional radiology

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Community Interventional Radiology

Frequently asked questions about UFE

Get answers to common questions about uterine fibroids and UFE procedure below. For additional information about UFE and treating uterine fibroids, visit

The particles are made of polyvinyl alcohol (PVA) or trisacryl gelatin (Embosphere® Microspheres). Both particle substances are medical grade material and FDA approved for embolization of vascular tumors. There is no silicone in PVA or embospheres. The FDA has approved biosphere embospheres specifically for use in the treatment of uterine fibroids.

During the procedure, the particles are precisely injected into the vessel(s) (uterine arteries and/or ovarian arteries) that provide blood flow to the fibroids. The particles become lodged within the tiny blood vessels that feed blood to the fibroids. This process is called “embolization” and stops the blood flow to the fibroids. Once the particles are in place, they stay put because the blood immediately clots in these tiny vessels, ‘trapping’ the particles. The particles remain in place as the fibroids shrink and do not break free. View a video clip >>

The UFE procedure provides treatment of all the fibroids present in the uterus at one time. The uterine arteries supply 99 % of all blood flow to the fibroids. By embolizing the uterine arteries, all of the fibroids are treated during a single procedure.

In a small number of women, the procedure may be performed more than one time due to continued blood flow to the fibroids after the initial UFE procedure. Typically, if there is another source of blood flow supplying the fibroids, it can be identified and treated during the initial UFE procedure.

Yes, UFE is successful with treating one or multiple fibroids. If the right and left uterine arteries are embolized, 99% of the blood flow to the fibroids is blocked. Once the blood supply to the fibroids is blocked, the fibroids can shrink up to 40-60%. If each fibroid shrinks approximately 40-60%, regardless of the number, there should be a significant reduction of symptoms.

Patients cannot feel the catheter moving inside the body or particles being injected into the uterine arteries. A local anesthetic is provided before the procedure to numb the area where the catheter is inserted. Additionally, medications are provided intravenously (through an IV) to keep you comfortable during the procedure.

Patients typically see an improvement approximately 4 to 9 weeks after the procedure. During the first or second menstrual cycle after the procedure, the same types of symptoms that were present before the procedure are typically still experienced. It is important to not get discouraged. By the third menstrual cycle after the procedure, a notable improvement in symptoms should occur. Fibroids may continue to shrink up to one year following the procedure, so continued improvement in symptoms may be expected.

You may experience a mild to moderate amount of pelvic cramping for approximately 4-6 hours after the procedure. Each patient experiences varying amounts of pain/cramping. However, our goal is to keep the cramping pain at a tolerable level with pain medication and nursing comfort measures.

You are able to control the amount of pain medication you receive by using a patient controlled analgesia pump (PCA pump). This pump delivers narcotic pain medication intravenously (through your IV) only when you push the control button allowing you to adjust the amount of pain medication based on your own, personal comfort level. The PCA pump is specially programmed so that you do no receive too much pain medication.

You may also experience nausea, which is controlled with medication. Typically, mild to moderate pelvic cramping continues intermittently for approximately one week to fourteen days following the procedure. To help keep pain at a tolerable level while recovering at home, you will be instructed on the use of ibuprofen, oral narcotic medications, and nursing comfort measures before leaving the hospital.

After embolization, some patients may experience “post embolization syndrome”. This is a combination of symptoms that occur approximately 3-5 days after embolization. The symptoms occur in response to cutting off the blood supply to the fibroids. This is a normal body reaction to the fibroid tissue dying and inflammation. Symptoms include fatigue, achiness, low-grade fever, and nausea. Many patients describe it as feeling like you have the “flu”. These symptoms usually go away in about 3-5 days. Patients may return to work one week after the procedure. This is an average recovery time; some women require more or less time depending on how they are feeling. Heavy lifting and strenuous exercise restrictions are suggested for 1-2 weeks after the procedure.

Embolizing the uterine arteries stops the blood supply to all of the fibroids present in the uterus. Once this blood supply is “blocked”, new fibroids typically do not grow. All of the fibroids may shrink about 40-60% after the procedure. Although the fibroids will always be present, they become small enough to relieve symptoms. Typically after the fibroids shrink, they do not grow larger at a later date.

For women over 45 years of age, the incidence of entering menopause increases to about 2-10% after UFE. In addition, if the fibroids are receiving blood flow from the ovarian arteries and these blood vessels are embolized, the chance of entering menopause after the procedure is slightly increased.

UFE is covered by most insurance companies for the treatment of symptomatic fibroids. It is not an experimental procedure and the particles used for embolization are FDA-approved for the treatment of vascular tumors. The FDA has approved biosphere embospheres specifically for use in the treatment of uterine fibroids.

You should contact your insurance company for particular details about coverage/eligibility and to determine if pre-certification/ preauthorization is necessary. Specifically, ask the following questions:

  • Is a referral required for consultation and is the interventional radiologist in your network?
  • Is pre-certification required for the pre-procedure pelvic MRI?
  • Is pre-certification required for the UFE procedure? Typically, our patients have an overnight stay in the hospital, but are released the next morning. UFE is considered an outpatient procedure.

Typically, our patients have an overnight stay in the hospital, but are released the next morning. UFE is considered an outpatient procedure.

Typically, the referring physician will fill out a referral/request for consultation form and pre-certify the patient for an initial consult (with an interventional radiologist) and treatment. During the consultation, the interventional radiologist will determine if the patient is a candidate for UFE based on clinical symptoms and medical history. Then, a pelvic MRI will be performed to determine if you are a good candidate, based on the size, location, and vascularity (blood flow) to the fibroids. Once the results of the MRI are known, the UFE procedure will be scheduled (if indicated).

The patient needs to contact their insurance company with their diagnosis, symptoms, previous treatment, and any previous imaging studies. The insurance company may need to know specific codes or more information than can be provided by the patient before it pre-certifies/authorizes the UFE procedure. In this situation, a direct phone number and name of the contact person from the insurance company should be provided to the interventional radiology office. Additionally, the patient should inform the office of the type of information the insurance company is requesting.

If you are any having the symptoms of fibroids, this should be discussed with your women’s health physician or gynecologist. Typically, a women’s health exam and an ultrasound is performed to determine the presence of fibroids. You may then be referred to an interventional radiologist to determine if you are a candidate for UFE and learn more about the procedure. Then, a pelvic MRI is typically ordered by the interventional radiologist to determine if you are a good candidate, based on the size, location, and vascularity (blood flow) to the fibroids.

  • <1 % uterine infection (infection of the uterus). Typically, treated with antibiotics. There have been a few cases of severe uterine infection reported in the United States. These resulted in additional medical treatment.
  • <1 % non-target embolization. Embolization (blocking the blood flow) of tissue other than fibroid tissue. Most common area of non-target embolization is tissue of the uterus. This occurrence may be mild and not require further treatment. However, it could be serious and result in additional medical treatment. There have been a few cases of non-target embolization reported in the United States.
  • <2 % hysterectomy related to a complication from the UFE procedure. Most common reasons for hysterectomy are uncontrolled uterine infection and non-target embolization of the uterus.
  • 2-10 % Menopause following the procedure (typically women over 45 years of age)
  • <5 % hematoma (bruising under the skin where the puncture site is made). This typically does not require further medical treatment.
  • A reaction to the special dye used during the procedure to help visualize the arteries. This is a rare occurrence.

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