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Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.

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Cystic Fibrosis Overview

What is cystic fibrosis?

Cystic fibrosis (CF) is an inherited disease characterized by an abnormality in the body's salt, water- and mucus-making cells. It is chronic, progressive, and is usually fatal. In general, children with CF live into their 30s.

Children with CF have an abnormality in the function of a cell protein called the cystic fibrosis transmembrane regulator (CFTR). CFTR controls the flow of water and certain salts in and out of the body's cells. As the movement of salt and water in and out of cells is altered, mucus becomes thickened. The thickened mucus can affect many organs and body systems including:

  • respiratory - sinuses and lungs
  • digestive - pancreas, liver, gallbladder, intestines
  • reproductive - more so in the male, where sperm-carrying ducts become clogged
  • sweat glands

There are about 30,000 people in the US who are affected with the disease, and about 1,000 babies are diagnosed with it each year. It occurs mainly in Caucasians who have a northern European heredity, although it also occurs in African-Americans, Asian Americans, and Native Americans.

Approximately one in 31 people in the US are carriers of the cystic fibrosis gene. These people are not affected by the disease, and usually do not know that they are carriers.

Click here to view the
Online Resources of Respiratory Disorders

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