Biliary Cirrhosis / Bile Duct Cancer
Biliary cirrhosis is a rare form of liver cirrhosis, caused by disease or defects of the bile ducts. Symptoms usually include cholestasis (accumulation of bile in the liver). There are two types of biliary cirrhosis:
- primary biliary cirrhosis - inflammation and destruction of bile ducts in the liver.
- secondary biliary cirrhosis - results from prolonged bile duct obstruction or narrowing or closure of the bile duct.
Next to gallstones, cancer is the most common cause of bile duct obstruction. The majority of bile duct cancers develop in the part of the ducts that are outside the liver and are sometimes referred to as extrahepatic tumors. Most bile duct cancers are adenocarcinomas which means they develop from the glandular cells of the bile duct.
The following are the most common symptoms of bile duct cancer. However, each individual may experience symptoms differently. Symptoms may include:
- jaundice - yellowing of the skin and eyes.
- abdominal pain
- poor appetite
- weight loss
- pale stools
- dark urine
The symptoms of bile duct cancer may resemble other medical conditions or problems. Always consult your physician for a diagnosis.
In addition to a complete medical history and physical examination, diagnostic procedures for bile duct cancer may include the following:
- ultrasound (Also called sonography.) - a diagnostic imaging technique which uses high-frequency sound waves to create an image of the internal organs. Ultrasounds are used to view internal organs of the abdomen such as the liver spleen, and kidneys and to assess blood flow through various vessels.
- computed tomography scan (CT or CAT scan) - a diagnostic imaging procedure using a combination of x-rays and computer technology to produce cross-sectional images (often called slices), both horizontally and vertically, of the body. A CT scan shows detailed images of any part of the body, including the bones, muscles, fat, and organs. CT scans are more detailed than general x-rays.
- magnetic resonance imaging (MRI) - a diagnostic procedure that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body.
- cholangiography - x-ray examination of the bile ducts using an intravenous (IV) dye (contrast).
- biopsy - a procedure in which tissue samples are removed (with a needle or during surgery) from the body for examination under a microscope.
- endoscopic retrograde cholangiopancreatography (ERCP) - a procedure that allows the physician to diagnose and treat problems in the liver, gallbladder, bile ducts, and pancreas. The procedure combines x-ray and the use of an endoscope - a long, flexible, lighted tube. The scope is guided through the patient's mouth and throat, then through the esophagus, stomach, and duodenum. The physician can examine the inside of these organs and detect any abnormalities. A tube is then passed through the scope, and a dye is injected which will allow the internal organs to appear on an x-ray.
Specific treatment for bile duct cancer will be determined by your physician based on:
- your age, overall health, and medical history
- extent of the disease
- cause of the disease
- your tolerance for specific medications, procedures, or therapies
- expectations for the course of the disease
- your opinion or preference
Treatment may include:
Surgery may be necessary to remove cancerous tissue, as well as nearby noncancerous tissue. Surgery may also be used to relieve blockage of the bile duct. Surgery may also be used to palliate or relieve symptoms.
- stent placement
If the bile duct is blocked due to cancer, a thin tube, called a stent, may be placed in the bile duct. It helps drain bile that builds up in the area. This is done to bypass the blockage that causes symptoms such as pain or yellow eyes and skin, called jaundice. A stent may be placed temporarily until surgery is performed to remove the tumor or a permanent stent may be placed.
- external radiation (external beam therapy)
External radiation is a treatment therapy that precisely sends high levels of radiation directly to the cancer cells. The machine is controlled by the radiation therapist. Since radiation is used to kill cancer cells and to shrink tumors, special shields may be used to protect the tissue surrounding the treatment area. Radiation treatments are painless and usually last a few minutes. Radiation therapy may be given after surgery, to kill small areas of cancer that may not be seen during surgery, or instead of surgery. Radiation may also be used to ease (palliate) symptoms such as pain, bleeding, or blockage.
Chemotherapy is the use of anticancer drugs to treat cancerous cells. In most cases, chemotherapy works by interfering with the cancer cell’s ability to grow or reproduce. Different groups of drugs work in different ways to fight cancer cells. The oncologist will recommend a treatment plan for each individual.
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