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Uterine Cancer

What is the uterus?

Illustration of the anatomy of the female pelvic area
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The uterus, also called the womb, is a hollow, pear-shaped organ located in a woman's lower abdomen, between the bladder and the rectum.

What are parts of the uterus?

  • cervix - the narrow, lower portion of the uterus
  • corpus - the broader, upper part of the uterus
  • myometrium - the outer layer of the corpus; the muscle that expands during pregnancy to hold the growing fetus
  • endometrium - the inner lining of the uterus

What is uterine cancer?

Cancers that occur in each part of the uterus have their own names, such as cervical cancer or endometrial cancer, but are sometimes broadly defined as uterine cancer because the structure is part of the uterus. Cancer of the uterus spreads through the bloodstream or lymphatic system and is the most common cancer of the female reproductive tract. According to the American Cancer Society (ACS), about 40,880 cases of cancer of the uterine corpus (body of the uterus) will be diagnosed in the US during 2005.

What are noncancerous conditions of the uterus?

Illustration of uterine fibroids
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Some conditions in the uterus, caused by abnormal, rapid, and uncontrolled division of cells, are not cancer. Three of these benign conditions include:

  • fibroid tumors - are common benign tumors of the uterine muscle that do not develop into cancer. Fibroid tumors of the uterus are very often found in women in their forties. And, although single fibroid tumors do occur, multiple tumors are more common.

    Symptoms of fibroid tumors, which depend on size and location, include irregular bleeding, vaginal discharge, and frequent urination. For fibroids that press against nearby organs and cause pain, surgery may be necessary. Many times, however, fibroids do not cause symptoms and do not need to be treated. After menstrual periods cease, fibroid tumors may become smaller and may disappear altogether.
  • endometriosis - is a benign condition of the uterus that is common among women in their thirties and forties, especially women who have never been pregnant. Tissue that looks and acts like endometrial tissue begins to grow in unusual places, such as on the surface of the ovaries, on the outside of the uterus, and in other tissues in the abdomen.
  • hyperplasia - is an increase in the number of normal cells lining the uterus. Although it is not cancer, it may develop into cancer in some women. The most common symptoms are heavy menstrual periods, bleeding between periods, and bleeding after menopause.
What is a risk factor?

A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases, including cancers, have different risk factors.

Although these factors can increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop cancer, while others develop cancer and have no known risk factors.

But, knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.

What are risk factors for uterine cancer?

The following have been suggested as risk factors for uterine cancer:

  • age 50 or over
  • history of endometrial hyperplasia
  • estrogen replacement therapy (ERT)
  • being overweight
  • diabetes
  • hypertension (high blood pressure)
  • history of other cancers
  • history of taking tamoxifen for breast cancer treatment or prevention
  • Caucasian women  

What are the symptoms of uterine cancer?

The following are the most common symptoms of uterine cancer. However, each individual may experience symptoms differently. Symptoms may include:

  • unusual vaginal bleeding or discharge
  • difficult or painful urination
  • pain during sexual intercourse
  • pain in the pelvic area

Cancer of the uterus often does not occur before menopause. It usually occurs around the time menopause begins. The occasional reappearance of bleeding should not be considered simply part of menopause. It should always be checked by a physician.

The symptoms of uterine cancer may resemble other conditions or medical problems. Consult a physician for diagnosis.

How is uterine cancer diagnosed?

When symptoms suggest uterine cancer, the following may be used to make a positive diagnosis:

  • a detailed medical history - family and personal
  • a thorough physical exam
  • pelvic examination of the uterus, vagina, ovaries, bladder, and rectum (may include a Pap test)
  • biopsy - removal of sample of tissue via a hollow needle or scalpel
  • dilation and curettage (D & C) - a minor operation in which the cervix is dilated (expanded) so that the cervical canal and uterine lining can be scraped with a curette (spoon-shaped instrument)

When cancer cells are found, other tests are used to determine if the disease has spread from the uterus to other parts of the body. These procedures may include:

  • blood tests
  • chest x-rays
  • computed tomography (CT or CAT) scans of various sections of the abdomen
  • an ultrasound to view organs inside the body
  • special exams of the bladder, colon, and rectum

Treatment for uterine cancer:

Specific treatment for uterine cancer will be determined by your physician based on:

  • your overall health and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference

Methods of treatment may include:

  • hysterectomy - surgery to remove the uterus
  • salpingo-oophorectomy - surgery to remove the fallopian tubes and ovaries
  • radiation therapy
  • hormone therapy
  • chemotherapy

Click here to view the
Online Resources of Gynecological Health

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